Russia launched a barrage of drones and ballistic missiles across broad swaths of Ukraine early Friday, killing at least six people and injuring dozens of others, days after Kyiv launched a daring raid on Moscow’s fleet of strategic bombers.

For residents of Kyiv, the night’s soundtrack was familiar: the shrieking whir of drones, air raid sirens and large explosions overhead – whether from air defenses successfully downing missiles, or projectiles puncturing the capital.

Three firefighters were killed in Kyiv, two civilians were killed in Lutsk, and another person was killed in Chernihiv, according to the Ukrainian State Emergency Service.

Ukrainian President Volodymyr Zelensky said Russia had used more than 400 drones and 40 missiles in the overnight attack, putting it among the war’s largest. He said Moscow’s attack injured 80 and targeted “almost all” of Ukraine, listing nine regions, from Lviv in the west to Sumy in the northeast.

Although Russia has pummeled Ukraine almost daily over three years of full-scale war, Ukrainians had been bracing for retaliation since Sunday, when Kyiv launched an audacious operation that struck more than a third of Russia’s strategic cruise missile carriers.

In a call with his US counterpart Donald Trump on Wednesday, Russian President Vladimir Putin said that Moscow would have to respond to Kyiv’s assault.