Lionel Messi scored twice in Argentina’s 2-0 win at Peru in a World Cup qualifier on Tuesday, playing the entire match for his national team. The 36-year-old appeared fit after he was sidelined for several matches with his club Inter Miami because of muscular pain

Also Tuesday, Brazil — the archrival of the defending World Cup champion — took two serious blows at Uruguay. Brazil lost 2-0 to the hosts, its first defeat in 37 World Cup qualifying matches, and saw its star Neymar leave the Centenario Stadium in Montevideo on crutches with a left knee injury.

Elsewhere, Venezuela beat Chile 3-0. Yeferson Soteldo opened the scoring shortly before the break, Salomón Rondón added a goal in the 72nd minute, and Darwin Machis scored seven minutes later. Last week, Venezuela earlier had a 1-1 draw against Brazil.

Argentina leads South American qualifying with 12 points in four matches. Uruguay, Brazil and Venezuela have seven points and are separated by goal difference. Colombia has six points, and Ecuador, Paraguay and Chile have four each. Peru has one point and Bolivia has zero.

The next World Cup in the United States, Mexico and Canada will include 48 teams, meaning direct entry for the top six teams in South America. The seventh-place team will contest an intercontinental playoff for a berth.